In recent years the reverse transcriptase enzyme telomerase, has attracted a lot of attention due to this enzyme over-?expression in 80-?85?% of cancer cell types. Inhibition of telomerase induces cell senescence and death and, for this reason, it has become a very important target for cancer therapeutics. Telomerase inhibition has been accomplished by inducing the folding of telomeric DNA into stable G-Quadruplex structures with small molecules. We here present the synthesis and preliminary telomerase inhibition studies of novel curcumin derivatives that could potentially pave the way to the development of novel anticancer drugs.

Synthesis and binding to telomeric DNA of novel curcumin analogs

248th National Meeting (2014)

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