The basic chromone structure has a variety of biological activities and has therefore been considered a privileged structure with regards to medicinal chemistry. Our research group recently developed new tin-free stereoselective additions to 3-formylchromones.More recently, however, we have been investigating a project that focuses on developing a variety new antimicrobial agents based on the chromone substructure. This is important due to the increasing problem of the formation of resistant strains of bacterial pathogens. This poster presents a convenient and versatile multisynthetic pathway to obtain small libraries of substituted 3-formylchromones. These products exhibit good to excellent cytotoxic activity against several human pathogenic bacteria, and have also shown cytotoxic effects against murine B16 melanoma cells.

Formyl chromones as privileged structures: Development of drug-like scaffolds with antimicrobial and cytotoxic properties

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.