Membrane proteins have received a lot of attentions as a target of drug development because of their crucial roles in various biological processes such as signal transduction, material transport and energy conversion. However, the functional and structural studies of membrane proteins are still challenging due to the technical difficulties in their handling in an aqueous solution. We have studied fabrication of well-defined nanoparticles encompassing a lipid bilayer as a novel platform for the analysis of membrane proteins. For the formation of lipid nanoparticles, we designed amphiphilic peptides, which can wrap the hydrophobic core of a lipid bilayer. In this presentation, we will discuss the effect of the peptide design on the interaction with lipid bilayer.

Designed amphiphilic peptides toward fabrication of lipid-peptide nanoparticles

248th National Meeting (2014)

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