1,4-Benzodioxin based natural products (see a sample structure below) possess various biological activities.  An inverse electron demand hetero-Diels-Alder reaction between o-quinones and enamines to prepare 1,4-benzodioxins has been developed. Characterization of different regioisomers was carried out with both X-ray diffraction chrystallography and density functional theory calculations.  Biological screening and regioselective synthesis will also be reported.

Preparation of 1,4-benzodioxins via <i>hetero</i>-Diels-Alder reaction

248th National Meeting (2014)

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Preparation of 1,4-benzodioxins via hetero-Diels-Alder reaction