By using materials from renewable resources such as glycerol and sugar alcohols (D-sorbitol, meso-erythritol and D-xylitol), biocompatible and biodegradable polyesters were enzymatically synthesized by using Candida Antarcticatype B (CAL-B) lipase. Due to regioselectivity of lipase enzyme, these multiple hydroxyl containing structures along with divinyladipate, produce linear polyesters possessing unreacted hydroxyl groups on their backbone. These aliphatic functional polyesters were hydrophilic in nature but only poly(xylitol adipate) and poly(sorbitol adipate) were water soluble.Modification of pendent hydroxyl groups with saturated and unsaturated fatty acids was carried out with different degree of substitution by using both bio and chemical catalysts. Poly(glycerol adipate) was enzymatically modified with oleic and linoleic acid however, poly(sorbitol adipate) was modified with stearoyl chain using chemical catalysis. Nanoparticles of these grafted polyesters were prepared by using interfacial deposition method. Dynamic light scattering measurements revealed nanoparticles with relatively narrow size distributions and with an average hydrodynamic radius of around 40 nm. All the synthesized products were characterized by NMR- and IR-spectroscopy and their thermal behavior was analyzed by DSC.

Preparation and characterization of nanoparticles from fatty acid modified polyesters

248th National Meeting (2014)

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