We report the unique thermoresponsive properties of fluorinated polyacrylamides, poly[N-(2,2-difluoroethyl)acrylamide] (P2F). The solubility of fluorinated polyacrylamides in water can be easily controlled by changing the number of fluorine atoms in N-ethyl groups. We demonstrate that the thermosensitivity of fluorinated polyacrylamides can be easily controlled by changing the number of fluorine atoms in the terminal alkyl group of N-ethyl moiety. Mono-fluorine substituted poly[N-(2-fluoroethyl)acrylamide] (P1F) is water-soluble while tri-fluorine substituted poly[N-(2,2,2-trifluoro-ethyl)acrylamide] (P3F) is water-insoluble. Interestingly, di-fluorine substituted poly[N-(2,2-difluoroethyl)acrylamide] (P2F) exhibits a LCST in water of around 26�28 oC, which is comparable to that of poly-(N-isopropylacrylamide) (PNIPAM). Moreover, we demonstrate that fluorinated polyacrylamides are less cytotoxic than poly(N-isopropylacrylamide) (PNIPAM).

Thermoresponsive fluorinated polyacrylamides for biorelated applications

248th National Meeting (2014)

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