Bacterial cellulose (BC) has been reported as the ideal material in the tissue repair fields, such as skin, bone, vascular and cartilage tissue regeneration [1-4]. Exploitation of the skin substitutes and modern wound dressings by using BC has attracted much attention [5]. The skin tissue repair materials based on BC have been biosynthesized, characterized and evaluated by Gluconacetobacter xylinus [6, 7]. Chitosan has excellent antimicrobial property and only one natural alkali polysaccharide. Thus chitosan is used in many applications, e.g., food, cosmetics, biomedical and pharmaceutical fields [8]. To develop an antimicrobial BC-based materials, BC/chitosan in-situ composites were produced by adding chitosan at different concentrations in the culture medium. Chitosan could be wrapped in the network of BC during its biosynthesis (Figure.1). XRD results indicated that the highest degree of crystallinity occurred when the medium contained 2% chitosan. The nanocomposites formed cohesive gel structures in SEM images. The results demonstrated that in-situ BC/chitosan nanocomposites have great promise and potential for skin tissue repair and wound healing.  Figure.1 Images of in-situ BC/CS nanocomposites. A & B: BC/1% CS, BC/2% CS, BC/ 3% CS and BC (left to right). Scale bar=5 cm. SEM: BC/1% CS, BC/2% CS and BC/ 3% CS (left to right). Scale bar=1 �m.References[1] Klemm, D., et al. Angew. Chem. Int. Ed., 2005 , 44(22), 3358-3393.[2] Wan, W. K.,et al. In ACS symposium series. Oxford University Press. 2006 , Vol. 938, pp. 221-241.[3] Czaja, et al. Biomacromolecules,  2007 , 8(1), 1-12.[4] Petersen, N., & Gatenholm, P. Appl. Microbiol. Biotechnol., 2011  , 91(5), 1277-1286.[5] Fu, L., et al.Carbohydr. Polym., 2013  , 92(2), 1432-1442.[6] Fu, L., et al. J. Mater. Chem., 2012 , 22(24), 12349-12357.[7] Fu, L., et al. Mater. Sci. Eng., C, 2013 , 33(5), 2995-3000.[8] Rinaudo, M. Prog Polym Sci, 2006 , 31(7), 603-632.

Preparation and characterization of bacterial cellulose/chitosan<i> </i>in situ composites for skin tissue repair and wound healing<i> </i>

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Preparation and characterization of bacterial cellulose/chitosan in situ composites for skin tissue repair and wound healing