Bis-ortho-chelated aryl-metal complexes, the socalled ECE-pincer metal complexes, exist in great varieties. Several novel strategies for anchoring these ECE-pincer metal complexes to soluble and insoluble supports have been developed. Key of this approach are the synthetic routes allowing for the direct introduction of functional para-substituents directly onto the preformed ECE-pincer metal complexes.1 For example, this allows the introduction of anionic tethers which can non-covalently bind the ECE-pincer metal complex to the core of multicationic core-shell dendrimers. Recently we concentrated on the covalent anchoring of ECE-pincer metal complexes to proteins.This approach, involving the inhibitory activity of nitrophenyl phosphonate esters to the catalytic triad (serine, histidine and asparagine) of lipases, has great potential for future applications in the fields of protein structure elucidation (NMR, X-Ray, mass spectrometry), medicinal chemistry (biomarkers, MRI contrast agents, radiopharmaceuticals), biomaterials and catalysis (enantioselectivity, catalysis in aqueous media). Crystal structures of these novel ECE-pincer metal-lipase hybrids show in detail how the ECE-pincer metal unit is covalently attached to the enzyme.2 The immobilization of such a catalytic hybrid on beads and their use for the dynamic kinetic resolution of a racemic alcohol will be demonstrated.31. Top Organomet Chem. 2013  , 40, 1�353.2. Chem.Eur.J. 2009  , 15, 4270-4280.3. Tet. Lett. ?2011  ?, ?52, 1601-1604.

Multifunctional NCN-pincer metal compounds: Polymers and hybrid catalytic materials

248th National Meeting (2014)

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