Exploration of novel small molecules from natural sources such as microbial metabolites, medicinal plants, and marine invertebrates has contributed to the dicovery of not only lead molecules for drugs but also research tools on chemical biology. Chemial biology based on forward/reverse chemical genetics is a new paradigm that accerelates drug development and the functional analysis of genes and proteins. We have discovered several novel bioactive metabolites by both in vivo cell-based phenotypic screenings and in vitrotarget-oriented screenings, and investigated their modes of action using a chemical genetics or a chemical genomics approach. In this special symposium, I will present chemical genetics approaches for apoptosis and angiogenesis signaling pathway as well as development of 5-SOxT probe for chemical tagging of a drug target using 5-sulfonyl tetrazole.

Chemical biology for drug discovery and target identification

248th National Meeting (2014)

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