Nanodiamond (ND) as an electrode material has excellent electrochemical properties, such as wide potential window, low background current, high chemical and electrochemical stability, excellent corrosion resistance and good biocompatibility. L-cysteine (Lcy) is an important thiol supply agent. When using the strong interaction between the gold surface and the sulfur atom above it, the biological molecules with specific function of self-assembly film can be obtained, and this has important significance in biology, pharmacology and bionics. In this work, Lcy was linked to the nanodiamond surface through organic reactions and mercapto nanodiamond (ND-Lcy) was obtained. ND-Lcy was modified on gold electrode by self-assembly, and the electrochemical sensing of ND-Lcy towards dopamine (DA) was investigated through cyclic voltammetry and chronoamperometry. The ND-Lcy/Au modified electrode exhibited good catalytic effect: the anodic peak current increased significantly, and the cathodic peak current also increased to some extent. At the same time, the anodic peak potential shifted negatively, while the cathodic peak potential shifted positively. Under the optimized experimental conditions, the current of DA had good relationship with its concentration in the range of 5.0 � 10-6 ~1.1 � 10-4 mol/L. The liner equation was I (�A) = - 0.0113c(�M) - 0.02771 (R = 0.9998) with a detection limit of 3.11 � 10-7 mol/L (S/N = 3).

Electrochemistry of mercapto nanodiamond self-assembly film

248th National Meeting (2014)

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