Monodisperse MnAu nanoparticles (NPs) with composition control were prepared via a seed-mediated and atomic diffusion approach and studied for H2O2 electrochemical detection. These MnAu NPs showed a composition dependent catalysis for H2O2 arising from the different degree of phase segregation in the surface activating post-treatment. Mn56Au44 NPs showed the best activity for H2O2 reduction among all MnAu and Au NPs, and reached a detection limit of 8 nM due to the core-shell type phase separation maximizing interfacial effect. These Mn56Au44 NPs were further proved to be sensitive for monitoring H2O2 generation from living cells and efficient in distinguishing tumorigenic cells from non-tumorigenic ones. This synthetic methodology provided a general approach for bimetallic NP synthesis and a new insight in NP biosensor design and application.

Monodisperse MnAu nanoparticles and their phase segregation for high sensitive H2O2 detection

248th National Meeting (2014)

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