Nanodiamond with low cytotoxicity is known as novel material which can pass through the blood brain barrier to provide treatments for many central nervous system disorders in recent years. Meanwhile, polymer is popular for controllable drug release design due to its stimuli responsive behavior with low critical solution temperature (LCST) 32�C. In this study, a sulfur functionalized DND is conjugated with Poly (N-isopropylacrylamide) (PNIPAM) to use as a drug carrier for the first time. Briefly, low temperature annealing is used to create surface defects on DND (SDND) to make it fluorescent and more hydrophilic. Furthermore, PNIAPM is functionalized SDND through a 'grafting from' method: PNIPAM is anchored onto SDND during the free radical polymerization process. This SDND/PNIPAM is used to deliver a FDA approved brain cancer drug-Temozolomide (TMZ) in vitro. TMZ is the only agent which changed clinical practice for GBM to prolong survival of patients. Its main effect is methylation of tumoral DNA to activate the apoptotic pathways causing tumor cell death. In the drug delivery, once the temperature of SDND/PNIPAM is above LCST, the particle will collapse and the hydrophilic TMZ will release. The releasing of TMZ carried by SDND/PNIPAM is carefully studied.

Poly (N-isopropylacrylamide) conjugated monodispersed fluorescent detonation nanodiamond for controllable temozolomide delivery

248th National Meeting (2014)

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