Poor solubility of water-insoluble drugs in aqueous solution can be a critical limitation to oral absorption therefore has hampered their use for disease treatments. In this work, a novel anti-cancer drug delivery system consisting of functionalized graphene oxide (GO) nanosheets and electrospray biocompatible gelatin nanospheres have been successfully developed. The chemical functionalization of GO by hydroxypropyl beta cyclodextrin (HPCD) were characterized by atomic force microscopy (AFM), transmission electron microscopy (TEM), Raman spectrum and high performance liquid chromatography (HPLC). The drug loading content (DLC) and drug loading efficiency (DLE) of Paclitaxel (PTX) included in HPCD were as high as 0.103 �g/mg and 59.5 %, respectively. The resulted PTX-GO-gelatin electrospray nanospheres were uniform in sizes of 200-500 nm. The concentration of gelatin in electrospray solution was found to be a key of generating the excellent nanospheres. Finally the in-vitro release profiles of PTX in the desired drug delivery system have been systematically investigated. The slow and smooth PTX release mechanism was discussed also. 

Functionalized graphene oxide drug delivery system as the unmodified paclitaxel carrier

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.