It has been shown that a variety of chemicals are not removed after wastewater treatment, which results in their release back into environment and water supply. These chemicals may act as endocrine disrupting compounds (EDC), which may affect the function of the endocrine system and adversely affect progeny. Studies evaluating the effects of EDC during periods of offspring development are lacking, including quantitative measures of accumulation after exposure. In this work, we are quantifying the transfer and accumulation of the EDC, triclocarban (TCC), from mother to offspring both in uteroand through lactation using accelerator mass spectrometry (AMS). The highly sensitive nature of AMS allows for assessment of environmentally relevant concentrations of TCC (pM-nM).  14C-labeled TCC was administered to pregnant female mice through their drinking water (100nM) during gestation or lactation using custom made water bottles. Detectable quantities of TCC were found in offspring for both exposure groups with the lactation group having three times the concentration (PND10 = 0.015%ID/g, ID = ingested dose) than the gestation group (GD18 = ~0.005%ID/g). An increase in average offspring weight for both groups was also noted when compared to their control counterparts; this increase was more significant for the lactation group, which contained the highest concentrations of TCC.  Taken together, these data indicate that TCC is transferred from mother to offspring through two routes: across the placental barrier and through lactation and that this exposure is associated with increases in offspring weight. While these effects were observed in mice, these findings suggest that if TCC is similarly transferred in humans, there may be implications after exposure on human health, in particular obesity.

Transfer of triclocarban from mother to offspring through gestation and lactation

248th National Meeting (2014)

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