Amphiphilic copolymers have the ability to self-assemble into a wide variety of morphologies in solution or in bulk giving soft materials such as spheres, rods, vesicles, micelles, nanofibers, and nanotubes for numerous applications such as drug delivery systems, nanoreactors and nanotemplates.To build amphiphilic copolymers, numerous hydrophobic blocks have already been linked to hydrophilic polyoxazoline. An interesting association concerns the lipids and the polyoxazoline named LipoPolyoxazoline (LipoPOx). Different lipidic derivatives (triacylglycerol, glycerol and fatty acid) can be explored.1 For instance, oxazoline monomers based on fatty acids have already been described and allowed the synthesis of amphiphilic copolymers with hydrophobic polyoxazoline block.2 The fatty (or alkyl) chains can also be employed in the synthesis of amphiphilic diblock copolymers using them as initiators or terminating agents. Moreover, the use of derivatives of glycerol (by-product of biodiesel) as initiators was investigated in the functionalization of polyoxazolines.3 Finally, the synthesis and the self-assembly in water of amphiphilic star copolymers were examined using functionalized vegetable oils to polymerize oxazolines.4,5Some of these synthetic routes would be detail in order to show the fruitful lipidic-POx combination. 1: R. Hoogenboom Eur. J. Lipid Sci. Technol. 2011 , 113, 59�71.2: Hoogenboom, R., Fijten, M. W. M., Thijs, H. M. L., Van Lankvelt, B. M., Schubert, U. S. Des. Monomers Polym. 2005 , 8, 659�671.3: Giardi C., Lapinte V., Nielloud F., Devoisselle J.M., Robin J.J. J. Polym. Sci. Part A: Polym. Chem. 2010 , 48, 4027-4035.4: Travelet C., Stemmelen M., Lapinte V., Robin J.J.,Dubreuil F., Borsali R. J. Nanopart. Res. 2013 , 15, 1626-1641.5: Stemmelen M., Lapinte V., Travelet C., Borsali R., Robin J.J. Polymer Chemistry 2013  , 4, 1445-1458.

LipoPOx: Partnership between polyoxazoline and lipids

248th National Meeting (2014)

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