In our laboratory, bis[(nonafluorobutane)sulfonyl]imide (Nf2NH) was used as a catalyst for the polycondensation, because of its high activity property. Furthermore, we also tried to use it as a new initiator for cationic ring-opening polymerization of 2-oxazolines.First, we investigated the polymerization activity and the livingness of N-methyl bis[(nonafluorobutane)sulfonyl]imide (Nf2NMe) which was derived from Nf2NH, acting as the new initiator for polymerization of 2-oxazolines. Cationic ring-opening polymerization of 2-ethyl-2-oxazoline proceeded in acetonitrile at 60 oC with Nf2NMe and compared it with methyl triflate (TfOMe) as current initiator.As the result, Nf2NMe had the similar polymerization activity to that of TfOMe. In addition, we confirmed the livingness by the two-step polymerization and 1H NMR spectrum.It is well-known that, poly(2-oxazoline)s have biocompatibility, so we next designed electrophoretic poly(2-oxazoline) to survey the application to biological materials conjugated with bioactive glass (Bioglass�45S5) which is silicate material found to bind directly to bone by electrophoretic deposition (EPD).We synthesized poly(2-oxazoline) having pendent sulfone [poly(sulfonyl-oxazoline)] by polymerization of sulfide-containing oxazoline, successive Oxone� oxidation (Mn=3.0�103, Mw/Mn=1.3) and conjugated bioactive glass by EPD. In consequence, the poly(sulfonyl-oxazoline)/bioactive glass composite could be deposited on a stainless-steel anode by EPD. Furthermore, after two weeks immersion in SBF (Simulated Body Fluid), we confirmed the appearance of hydroxyapatite on the poly(sulfonyl-oxazoline) / bioactive glass composite film.These fundamental results provide new biological material having biocompatibility and characteristic of bone regeneration using EPD technique.

Design of electrophoretic poly(2-oxazoline)s using sulfoneimides as the initiator and hybridization with bioactive glass

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.