Self-assembled monolayers have been the workhorse for nanotechnology since a few decades. They constitute an interface and �interphase� between a substrate and the �outside world�. Their functions are by far not only the basic types such as substrate protection, anchoring and tuning of hydrophilicity, but have progressed into ever increasing added value ranging from molecular recognition (e.g. for sensing), molecular construction, biomolecular orientation, electronic transport, signalling, etc.Reactive monolayers, i.e. monolayers that have some reactive moiety at the headgroup that allows further functionalization, form a subclass that is extremely useful for molecular (nano)fabrication. The reactivity of such monolayers can be the same or drastically different (faster or slower) than of their solution analogs. The development of a responsive thiol-reactive platform that signals attachment reactions occurring onto them is useful for biomolecular arrays.[1-3] Surface gradients have been developed using a microscale electrochemical reaction-diffusion system, and used to address and map reactivity profiles on surfaces on reactive monolayers.[4,5]The current presentation will focus on new developments by the combination of the responsive platform and gradient technology with host-guest systems in order to provide new tools to study multivalent recognition processes that show out-of-equilibrium self-assembly or superselectivity. References[1]    C. Nicosia, J. Cabanas-Dan�s, P. Jonkheijm, J. Huskens, ChemBioChem 2012 , 13, 778.[2]    J. Cabanas-Dan�s, C. Nicosia, E. Landman, M. Karperien, J. Huskens, P. Jonkheijm, J. Mater. Chem. B 2013 , 1, 1903.[3]    D. Wasserberg, C. Nicosia, E. E. Tromp, V. Subramaniam, J. Huskens, P. Jonkheijm, J. Am. Chem. Soc. 2013 , 135, 3104.[4]    S. Krabbenborg, C. Nicosia, P. Chen, J. Huskens, Nature Commun. 2013 , 4, 1667.[5]           C. Nicosia, S. O. Krabbenborg, David N. Reinhoudt, J. Huskens, Supramol. Chem. 2013 , 25, 756.

Covalent and noncovalent chemistry in a reaction-diffusion system: Out-of-equilibrium self-assembly and superselectivity

248th National Meeting (2014)

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