Several racemic pesticides were tested, of which various samples were separated using Regis saccharide-based coated and covalently bound chiral stationary phase under normal phase HPLC and SFC conditions. The influence of mobile phase composition on the separations was investigated. The mobile phases were methanol/carbon dioxide, ethanol/carbon dioxide, or isopropanol/carbon dioxide with UV detection. The effects of additives were also investigated and methods toward preparative scale isolation were developed.

Chiral resolutions of commercial racemic pesticides by SFC: Applications in analytical and preparative scales

248th National Meeting (2014)

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