We have found that it is often possible to replace a cyclic imine moiety in a heterocycle with a cyclic amide.  This has been successfully demonstrated in sulfonylureas and tubulin fungicides among others.  In this poster we will describe further examples of both successful and unsuccessful use of this bioisosteric replacement strategy.  

Cyclic imine/cyclic amide bioisosterism as a tool for the discovery of new biologically active compounds

248th National Meeting (2014)

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