This lecture will detail the route discovery and development efforts that culminated in a convergent synthetic route capable of producing commercial quantities of drug substance. The technical perspective will include discussion on an asymmetric approach as well as a more traditional resolution approach. In addition, an unusual Pd-catalyzed C-H arylation reaction on pilot scale will be discussed. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/241nm/uploads/71681_figure1.jpg' alt='' />

Route discovery and process development of BMS-791325: A pharmaceutical development candidate for the treatment of hepatitis

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.