Amino acid bearing degradable polyesteramides (PEA) are the next stage of evolution in degradable polymers from aliphatic polyesters to nitrogen bearing polymers such as polyurethanes, polyester amides and polyureas. The pursuit of these changes has been to achieve better control over biocompatibility, degradation and release properties for medical and pharmaceutical applications. Incorporation of amino acid-based building blocks offers not only metabolizable units, but also reactive sites that allow further modification of the polymer to tailor physicochemical properties, tune cellular response and degradation.PEAs are based on a-amino acids, aliphatic dicarboxylic acids and aliphatic a-? diols.  1 Among this class of polymers it is the AA-BB hetero-chain polymers that offer the greatest versatility in terms of molecular level design to tailor drug release properties.  Schematic representation of the amino acid based biodegradable polyesteramides for drug delivery and applications as coatings, injectable microspheres and fibrilsThese PEAs allow with minimal chemical modification the tailoring of degradation to be either predominantly enzymatic or hydrolytic.2 Furthermore these polymers degrade without a significant lowering of pH an effect known to aggravate inflammation and foreign body response. In this lecture we will describe how the degradation characteristics are tailored, elaborate on the degradation mechanism and breakdown products3 as well as present in vitro � in-vivo correlations.The biocompatibility of these materials and their use as coatings, microparticles and fibres will be presented in applications such as a drug eluting stent where these materials are in a clinical trial and as injectable formulations for osteoarthritis in an orthopedic setting and for treatment of glaucoma in an ocular setting.4References1. G. Tsitlanadze, T. Kviria, R. Katsarava, C.C. Chu, Journal of Materials Science: Materials in Medicine 15 (2004) 1852. DSM Patents: WO2007107358, WO2008055666, US8445007, EP1926780, WO2012175746, WO20121757483. A. Ghaffar, et al., Biomacromolecules 12 (2011) 3243-32514. M. Kropp, et. al. Polymers,  (2014), 6(1), 243-260,

Amino acid based biodegradable polyesteramides for drug delivery

248th National Meeting (2014)

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