Matrix effects can be our friend, leading to lower limits of detection and quantification for GC based pesticide residue analysis; or our foe, making quantification problematic. In order for the matrix effects to be harnessed to our advantage, we need to understand them and to learn how to control them. Calibrations using standards in solvent, matrix matched standards, standards with analyte protectants, standards with grain matrix, standards with analyte protectants and grain matrix, and standard addition will be compared. Case studies for the use of grain matrix, together with analyte protectants, to further enhance detection limits for residues and endogenous analytes in food, environmental samples and plant material will be presented with optimisation compared pesticide class. A robust quantification procedure for residues and endogenous analytes in food, environmental samples and plant material will be proposed.

Matrix effects: Friend and foe for quantification of residues and endogenous analytes

248th National Meeting (2014)

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