Bioaccumulation potential of chemicals is typically assessed from bioconcentration, conventionally measured according to Test Guideline (TG) OECD 305. This study type is a regulatory requirement for a chemical with properties that suggest that it has the potential to bioaccumulate, i.e., Kow = 3.0 and when its use may result in the exposure of aquatic organisms to the test chemical in aquatic environments. Historically, the test is performed by exposing a group of fish to the test substance at two concentrations in a flow-through test system. The new revised TG (October 2012), consistent with the three R's, has proposed the use of a single exposure concentration in order to use fewer fish primarily for animal welfare reasons. However, the revised design is more cost-effective as well. This presentation is a comparative analysis of data to demonstrate that for many classes of compounds, the bioconcentration factor (BCF) is independent of exposure concentration and confirm that one exposure concentration is a scientifically sound method to determine a fish BCF.

Comparative analysis of fish BCF results of various compounds obtained from exposure to high and low chemical concentrations in a flow-through systems

248th National Meeting (2014)

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