When conducting environmental fate studies the use of radiolabelled test substance allows the rate and route of dissipation and transformation of the test substance to be followed. In order to achieve these objectives it is necessary to obtain a mass balance in the range of 90 to 110% of the amount of radioactivity applied. If the test substance is volatile, obtaining an acceptable mass balance can be challenging. Each test substance has different properties and so will require different solutions. In addition, if the test substance degrades, it is often necessary to trap, quantify and identify a range of volatile radiolabelled degradation products. Different approaches to solving the problems associated with the conduct of studies using volatile test substances will be presented.

Solving the challenges posed when conducting environmental fate studies with volatile test substances

248th National Meeting (2014)

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