In-house knowledge has always been considered a valuable asset for any company in the pharmaceutical industry. Adequate management of this wealth of intellectual information, facilitating re-use of existing expertise instead of redundant experimental studies, is among the primary objectives of any organization striving to make drug development process more cost-effective. This work introduces ACD/Percepta Portal � a new platform that combines well established components of the ACD/Percepta software (predictive algorithms, structure design engine, databases, etc.) with the flexible network based deployment, raising software interactivity to a new level and offering some exciting features.A particular focus of this presentation will fall on the components of the ACD/Percepta Portal that enable utilizing wisdom of the crowd within the company. The workflow starts in Drug Profiler that provides a quick summary of all relevant information about the posted chemical structure, and brings up a virtual discussion board in order to get a live feedback from the company peers working in other departments and involved in various projects. The response comes in the form of favorable/unfavorable votes that can be accompanied by comments containing any arguments for a particular opinion. The size of the �crowd� involved as well as the weight of the input from a particular group of voters can be easily adjusted, for example, depending on the project phase. The voting feedback can subsequently be used in compound ranking, alongside their PhysChem & ADME/Tox profiles and any other in-house data. Wrapped up in an intuitive visual interface, this medicinal chemistry �social network� adds a new dimension to the process of knowledge sharing within the company. As a result, ACD/Percepta Portal transforms the usual drug-discovery project workflow within a dedicated group into an interactive company-wide endeavor.

ACD/Percepta portal: Crowdsourcing in medicinal chemistry projects

248th National Meeting (2014)

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