Asthma is a condition in which airway smooth muscles(ASM) become constricted and swell. The extra mucus created reduces the flow of air in and out of the lungs. Medications are available to promote ASM relaxation and/or suppress local immune/ inflammatory processes by inhaling corticosteroids and �-adrenergic antagonists and out of them promoting airway smooth muscle relaxation would be clinically valuable.1 Activation of ASM GABAA receptors with agonist (8-methoxy imidazobenzodiazepine (CMD-45)) selective for these subunits resulted in appropriate membrane potential changes, chloride currents and promoted relaxation of ASM. Given the absence of a6 subunit expression this drug truly targeting the a4 containing GABAAreceptors. Recently a series of new subtype selective Bz/GABAergic ligands have been developed based on the SAR of CMD-45 and will be presented in this poster.

Inducing airway smooth muscle relaxation by targeting the restricted a-subunit repertoire of GABA<sub>A</sub> receptors using CMD-45

248th National Meeting (2014)

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Inducing airway smooth muscle relaxation by targeting the restricted a-subunit repertoire of GABAA receptors using CMD-45

Inducing airway smooth muscle relaxation by targeting the restricted a-subunit repertoire of GABA_A receptors using CMD-45