CXCR4 is a chemokine receptor that has been linked to various disease pathways including: HIV-1 proliferation, auto-immune disorders, inflammatory disease and cancer metastasis. The interaction of the C-X-C chemokine receptor type for (CXCR4) with C-X-C chemokine ligand 12 (CXCL12) plays an important role in triggering these disease related pathways. Various antagonists for CXCR4-CXCL12 interaction have been synthesized and tested, but many are not useful clinically. This work focuses on the design and synthesis of a new class of compounds that show potential as CXCR4 antagonists. Upon synthesis, these compounds were tested using an affinity binding assay and a cell invasion assay to asses activity. A few hit compounds have been identified and all structures have been confirmed by spectroscopy analysis.

Synthesis of pyridine and thiophene derivatives as potential antagonists of chemokine receptor type-4

248th National Meeting (2014)

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