A series of 24 compounds that comprise pyrrolyl- 1,3,4-oxadiazole and pyrrolyl- 4-aminoantipyrine pharmacophores were subjected to Molinspiration virtual screening protocol, compounds with maximum predicted drug-likeness model score among the series were synthesized and screened for anticancer and antioxidative activities. The anticancer activity against a panel of prostate cancer cell lines and breast cancer cell lines displayed moderate inhibitory activities. Among the synthesized compounds, compound 4 and 7 with pyrrolyl-1,3,4-oxadiazole moiety emerged with moderate antioxidant (DPPH test) as well as anticancer agent for further investigation.

Synthesis, anticancer, and antioxidant activities of some pyrrolyl-1-3,4-oxadiazole and pyrrolyl-4-aminoantpyrine Schiff base analogs

248th National Meeting (2014)

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