Compound 1  is a potent 11 Beta HSD-1 inhibitor.   A convergent and efficient synthesis was developed to support pharmaceutical development needs.  Target molecule 1  contains a synthetically challenging [2.2.1]bicyclic side chain and a bi-aryl ether functionality.  In this presentation, details of a novel synthesis of 1  in addressing many synthetic challenges along with details of process development work that enabled this synthesis on scale will be provided.

Highly efficient and novel synthesis of a potent 11 beta-HSD-1 inhibitor containing a [2.2.1]bicyclic functionality

248th National Meeting (2014)

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