SDHI fungicides inhibit the enzyme succinate dehydrogenase within the fungal mitochondrial respiration chain. The enzyme SDH consists of four subunits and the binding site is formed by the subunits B, C and D.The increasing usage of SDHIs exerts significant selection pressure to plant pathogens. Thus, the occurence of SDHI resistant isolates has been already reported for important pathogens such as Botrytis cinerea, Alternaria alternata, or Pyrenophora teres. Several single target site mutations have been detected which often occur at different positions or subunits of the target enzyme, dependant on the pathogen. Recent research showed that different mutations could have a varying impact on the activity of individual SDHIs.Details on the mode of action and on the consequences of different target site mutations for the performance of the entire group of SDHI fungicides are discussed.

SDHIs - mode of action and resistance mechanisms of this new generation of fungicides

248th National Meeting (2014)

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