It is well known that the electrospray ionization mass spectrometry (ESI-MS) sensitivity is largely determined by the ionization efficiency and the ion transmission efficiency at the ESI-MS interface. The ion losses at the ESI-MS interface can be effectively eliminated by operating electrospray at subambient pressures in the first MS vacuum chamber and the ESI efficiency can be greatly enhanced by using an array of electrosprays at a given flow rate. We present our latest development on a new subambient pressure ionization with nanoelectrospray (SPIN) source incorporating a chemically etched ESI emitter array with individual sheath gas and its performance evaluation on further increasing the overall ESI-MS sensitivity highlighting another unique utility of the ion funnel in the MS instrumentation.

Electrodynamic ion funnel: A critical component enabling the nanoESI emitter array/SPIN source for high sensitivity MS

248th National Meeting (2014)

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