The Threshold of toxicological concern (TTC) approach has been put forward as a tool for assessing substances of unknown toxicity present at low levels in human diet and potentially other routes of exposure. The use of the TTC approach as a pragmatic tool for assessment and priority setting for regulatory decision making in several areas of chemical risk assessment will be discussed. There will be a particular focus on the use of the TTC approach in Europe for metabolites of plant protection products as proposed by the European Food Safety Authority. The reasons for limited application of the TTC approach for chemical assessment under the European REACH regulation will be discussed. The advantages and disadvantages of the TTC approach will be outlined.

Threshold of Toxicological Concern and its use in agrochemical and chemical risk assessment

248th National Meeting (2014)

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