Intensive competition for intellectual property, easy development of agrochemical resistance, and stricter regulation for environmental protection make the successful rate for agrochemical discovery extremely low using traditional agrochemical discovery methods. Therefore, a novel approach is urgently needed to guide agrochemical discovery with high efficiency to keep pace with a changing market. We will summarize the Intermediate Derivatization Method (IDM) between conventional methods in agrochemicals and novel ones in pharmaceuticals. This method is relatively efficient with short time in discovery phase, reduced cost, especially good innovated structure, and better performance. We will summarize and illustrate what IDM is and how and why to use it to accelerate the discovery of new biologically-active molecules, focusing on agrochemicals. We will present several research projects in our novel agrochemical discovery program with improved success rate under guidance of this strategy in recent years.

Efficient approach for discovery of novel agrochemical candidates

248th National Meeting (2014)

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