Aromatase and 17-�HSD inhibitors are main target of pharmacological interest for the treatment of estrogen dependent cancers. Chalcones, Coumarins, Flavones, Isoflavones have been reported for such inhibition and are used for treatment of breast tumors. Flavone derivatives containing Imidathiadiazole, Thiadiazole, Triazole and benzimidazole hetrocycles derivatives are synthesize by using simple laboratory reagents like 2-Hydroxy Acetophenone and 4-Hydroxy Benzaldehyde to convert chalcone leads to formation of Flavones by cyclization using Microwave and followed by attachment of different hetrocycles to form Flavone derivatives and which can be characterize by IR, 1H NMR, 13C NMR spectroscopy and elemental analysis.  

Synthesis of new flavone derivatives against estrogen dependent cancers

248th National Meeting (2014)

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