The incidence of cutaneous malignant melanoma has been rising during the past decade. Once disseminated, malignant melanoma is associated with a very poor prognosis. Despite a large number of clinical trials with various chemotherapeutic agents and biological modifiers, an effective treatment is still lacking.  Glutathione disulfide (GSSG) is an endogenous, cell membrane impermeable, oxidized form of glutathione (GSH). We have developed a GSSG cationic liposome formulation that effectively delivers GSSG into cells leading to a 20 fold increase in intracellular GSSG. We found that the GSSG liposomes effectively inhibited the growth of murine B16F10 melanoma cells. An in vivo experiment with B16F10 melanoma cells implanted subcutaneously in syngeneic C57BL6 mice demonstrated that the GSSG liposomes effectively inhibited the tumor progression and doubled the survival rate.

Growth inhibition of malignant melanoma by glutathione disulfide liposomes

248th National Meeting (2014)

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