Cancer metastasis is associated with more than 90% of cancer mortality, hence considered the terminal stage for the patient. Despite extensive research efforts, no effective anti-metastatic drugs are available. Glutathione disulfide (GSSG) is an endogenous and cell membrane impermeable peptide. We have developed a cationic liposome formulation that effectively delivers GSSG into cells leading to a 20 fold increase in intracellular GSSG. Through the use of B16F10 murine melanoma cells, we found that the GSSG liposomes completely prevented key steps involved in cancer metastasis, namely cell detachment and migration. GSSG liposomes also significantly inhibited cell invasion in vitro. Through a well-established murine melanoma metastasis model with C57BL6 mice and B16F10 cells, it was shown that GSSG liposomes completely prevented pulmonary metastasis. The results reveal GSSG liposomes could be very effective in the treatment of metastatic cancer.

Anti-metastatic effects of glutathione disulfide liposomes

248th National Meeting (2014)

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