Natural product inspired building blocks can be potential starting points in drug discovery given their desirable physicochemical attributes. This poster highlights the use of a core generated from natural product Asperparaline A and synthesis of library of compounds. Pauson-Khand cyclization of enyne 4  enabled the rapid assembly of tricyclic core 6   and further elaboration provided structurally diverse compounds for screening.

Natural product inspired libraries for hit generation in drug discovery

248th National Meeting (2014)

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