Fluopicolide and Fluopyram are two crop protection products recently launched by Bayer CropScience for the control of several key diseases in the Fruits & Vegetables market. Very surprisingly, both innovative active ingredients have closely related chemical structures but different modes of action and spectra of activity. While Fluopicolide controls downy mildews, late blight and various Pythiumspecies by acting on the spectrin-like distribution, Fluopyram is a structurally new SDH inhibitor which controls many diseases such as powdery mildew, botrytis, sclerotinia, and monilinia. Structural similarities are due to the presence of the same and unique 5-chloro-3-(trifluoromethyl)pyridin-2-yl residue in their amine backbones. Several approaches to synthesize the commercial products will be described. Access to novel trifluoromethoxy substituted pyridines as useful scaffolds in Agrochemistry will be also discussed.

From a unique pyridine to fluopicolide and fluopyram

248th National Meeting (2014)

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