We investigated the formation of the oligomeric forms of amyloid beta peptide (A�1-42) over the nanogold colloidal particles' surfaces under the temperature ranging between 10�C and 50 �C. The diameter of nanoscale gold colloid used was between 10 nm and 100 nm, and a significant sign of self-assembly was observed only for 20 nm and 30 nm gold colloids at 20 �C. It implies that oligomers may construct a cage-like structure with a diameter of 20 or 30 nm. Furthermore, we measured the threshold pH value (pHo) supports unfolded conformation. There were no significant colloidal size dependence in pHo. However, it exhibited a non-monotonic feature in temperature dependence.

Temperature  dependence of reversible self-assembly of A�<sub>1-42</sub>  over gold colloidal nanoparticle

248th National Meeting (2014)

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Temperature dependence of reversible self-assembly of A�1-42 over gold colloidal nanoparticle

Temperature dependence of reversible self-assembly of A�_1-42 over gold colloidal nanoparticle