Viral nanoparticles can serve as powerful platforms to display multivalent functional groups for biomedical application by orthogonal bioconjugation and supramolecular strategy between host and guest molecules. Such multifunctional TMV can load with orthogonal imaging agents, targeting ligands and drugs in one-pot approach. In addition, we showed that, through chemical modification, tobacco mosaic virus (TMV) and cowpea mosaic virus (CPMV) can be employed as effective carriers to display small molecule haptens in high density and ordered pattern with improved humoral immune responses in vivo.

Tobacco mosaic virus as polyvalent scaffold to stimulate humoral immune responses

248th National Meeting (2014)

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