Cancer is a complex and multifactorial disease accounting for more than ten million new cases every year. Nanotechnology platforms with high target specificity and minimum collateral damage and immune reaction are currently under development. Nanoscaled metal-organic frameworks were produced and characterized, which showed versatile vectors for theranostics applications with a significantly high cytotoxicity to Chinese hamster ovarian (CHO) cancer cells. To fully understand the therapeutic efficacy and mechanism of CHO cancer damage, we took these steps: 1) nanomaterials synthesis; 2) fine structural characterization; 3) properties measurement; and 4) the efficiency of the theranostics analysis. In-vitro toxicity data indicated that PCN-95 IC50 (0.02 ppm) is comparable to, or lower than the current first-line drug formulations; at higher doses, the kinetics of action were approximately ten-fold higher. These biological effects may be attributed to the unique tetra-topic carboxylate ligand bridging to a bimeric �3-H2O-centered cluster, in addition to high crystallinity and high aspect ratio.

Investigation of nanostructured metal-organic frameworks used in cancer research

248th National Meeting (2014)

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