Reactive oxygen species (ROS) including hydrogen peroxide have been shown to play an important role in the development and progression of cancer.   The aim of this project is to develop a PET probe capable of sensing hydrogen peroxide in tumor microenvironments.  Toward this goal we have developed new radiochemical methods for incorporation of H2O2-labile chemistry into 18F tracers. Here we report the radiosynthesis of 18F H2O2-labile prodrugs and their peroxide-dependent uptake in UOK 262 cells in vitro.

Radiosynthesis of H2O2- labile 18F prodrugs for ROS sensing

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.