Antibiotic resistance is a global health crisis.  This year in the United States, approximately 2 million people will acquire infections resistant to at least one antibiotic and of those an estimated 23,000 people will die. While better antibiotic stewardship is believed to be capable of slowing the spread of this resistance, in order to combat these infections novel antibiotics with activity against resistant strains are needed.  Recently, a novel antibiotic with activity against antibacterial resistant bacteria was discovered.  Herein we describe the total synthesis of this molecule as well as further evaluation of its antibacterial activity and mode of action.

Synthesis and biological evaluation of compounds with activity against antibacterial resistant bacteria

248th National Meeting (2014)

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