Iron-sulfur proteins are one of the main reaction sites of NO, wherein [Fe-S] clusters become modified and convert to various iron nitrosyls including dinitrosyl iron complexes (DNICs). Although it is known that DNICs are the result of the degradation of [Fe-S] clusters by NO, it is not well understood what other product(s) besides DNICs may form during the cluster degradation nor what DNICs and other degradation product(s) can do once they are generated in cells. Using a synthetic modeling approach, we have found that the bridging sulfides of [2Fe-2S] clusters can be released as H2S upon nitrosylation under various reaction conditions. We will describe nitric oxide reactivity of discrete [2Fe-2S] clusters in the presence of acid or hydrogen atom donors leading to H2S generation. Additionally, the reverse process, the repair chemistry of [2Fe-2S] cluster from iron nitrosyls, will be described.These studies were supported by the National Science Foundation (CHE-1254733)

Nitric oxide reactivity of synthetic [2Fe-2S] clusters

248th National Meeting (2014)

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