The lecture will focus on our efforts to create bright fluorescent labels based on DNA-templated multichromophore arrays. Our approach relies on the use of nanostructured DNA as a scaffold on which to assemble dozens of fluorescent intercalator dyes within a confined space without self-quenching. The resulting supramolecular fluorophores offer exceptional brightness due to their high molar extinction coefficients. These DNA �nanotags� feature efficient FRET, allowing straightforward tuning of emission wavelengths, high stability (enzymatic and photochemical) and modular assembly from commercially available components.

DNA nanotags:  Bright fluorescent labels based on intercalating dyes and DNA nanostructures

248th National Meeting (2014)

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