A chemical series has been highlighted with potent, broad spectrum fungicidal activity in Syngenta's in-house biology screens and this glasshouse activity was shown to translate to field performance. Early assessment indicated inhibition of protein kinase enzymes might be responsible for the observed fungicidal effect. Subsequent protein kinase profiling screens revealed that the chemistry is selective; inhibiting only a small number of protein kinases. Chemical proteomics strategies were employed for target identification in Zymoseptoria tritici and continue to emerge as an attractive tool for probing ligand-protein interactions. Tools for structure activity determination were developed to support the lead generation pipeline. We will share some of the work done to understand the mechanism of action of this chemical class in fungi relevant to agriculture.

Elucidation of a novel protein kinase target in fungicide research

248th National Meeting (2014)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.