We prepared amide derivatives and examined their antimicrobial activity for the purpose of discovering a new fungicide for Oomycetes. Activity enhancement and reduced phytotoxicity were accomplished by structure optimization from the lead compound. For thiazole amide derivatives, the high effect against Phytophthora infestans was confirmed in field studies. We report structure-activity relationships and structure optimization about these amide derivatives in this poster.

Discovery and optimization of amide fungicides

248th National Meeting (2014)

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