A new series of synthetic protein transduction domain mimics (PTDMs) was designed based on key parameters of Pep-1 and TAT.  These novel PTDMs were significantly more active than either Pep-1 or TAT alone.  To better understand the importance of guanidine and phenyl groups segregation along the backbone both membrane interactions and cellular internalization studies were conducted.  The results showed that functional group segregation impacts activity.  Their ability to deliver active peptides, proteins, and antibodies into primary T-cells was exploited This study gives new design guidelines for the development of PTDMs.

Synthetic mimics of protein transduction domains: New opportunities for T-cell biology

248th National Meeting (2014)

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