Visible light photoredox catalysis is employed for the C�H amination of arenes and heteroarenes, and selective anti-Markovnikov hydroamination of alkenes. The methodology utilizes electron deficient N-acyloxyimides as precursors for the generation of stable N-centered radicals. The reaction features the meta-selective amination of pyridine derivatives, and the hydroamination of unactivated alkenes. Modification of the electronic and steric properties of the aminating reagent provides a wide range of nitrogen-based radicals. Additionally, the reaction's mild conditions offer the opportunity for the functionalization of complex organic and biologically relevant molecules.

N-acyloxyimides as nitrogen radical precursors in the visible light photocatalyzed amination and hydroamination of organic molecules

248th National Meeting (2014)

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