Magnesium dialkylaminoborohydrides (MgAB) are a new class of powerful yet selective reducing agents. These compounds are strong reducing reagents like LiAIH4, capable of reducing a wide variety of functional groups, but are chemoselective, more stable, and safer to use. MgAB reagents are prepared by the reaction of a Grignard reagent with an amine-borane under ambient conditions. MgAB's can be handled in dry air as easily as sodium borohydride and retain their chemical activity for at least 3 months when stored under inert atmosphere. Aldehydes and ketones are reduced to the corresponding alcohol in 15�30 minutes at room temperature. Tertiary amides are reduced at room temperature to the corresponding aldehydes.

Synthesis and utility of magnesium dialkylaminoborohydrides: A new class of powerful, selective, air-stable reducing agents

248th National Meeting (2014)

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